On a classic tour of Rome, focus on the great masters from the Renaissance to the Baroque, whose works define the opulence of this incomparable city. Stroll through lively piazzas, walk down cobbled streets, and step inside palatial residences. Experience the awe-inspiring Vatican, whose world-class museum collections showcase the city's power to attract the greatest artists of their times. Meet a Carmelite monk to tour the oldest pharmacy in Rome. Revel in an exclusive after-hours tour of the Villa Farnesina, whose interior is decorated with frescoes from artists including Raphael. Enter the world's oldest academy, which counted Galileo among its members. And wander around the dramatic fountains at 16th-century estate of Villa d'Este. Accommodations are at the luxurious Hotel Splendide Royal.